Drug safety crackdown revs up

NF1 inactivation revs up Ras in adult acute myelogenous leukemia.

Mutations in the Ras pathway are common in myeloid malignancies. NF1, a tumor suppressor and negative regulator of Ras, is inactivated in a subset of adult acute myelogenous leukemia (AML) cases. Loss of NF1 function sensitizes cells to inhibition of mammalian target of rapamycin (mTOR), a downstream effector of Ras activation, highlighting a potential therapeutic opportunity for some AML patie...

Withdrawal of rofecoxib - a wake up call for drug safety.

yclooxygenase-2 (COX-2) inhibitors have been developed with the goal of providing similar efficacy and greater safety, compared with that of traditional Non-Steroidal Anti Inflammatory Drugs (NSAIDs). United States Food and Drug Administration (USFDA) has approved rofecoxib in May 1999 for the reduction of pain and inflammation caused by osteoarthritis, as well as for acute pain in adults and f...

United States Food and Drug Administration signals crackdown on caffeinated alcohol drinks.

has dealt what could be a death blow to caffeinated alcoholic energy drinks that federal officials said can leave people “wide-awake drunk” and more prone to risky behaviour. The premixed caffeine-alcohol combinations — especially popular with college students and other young people — should soon be gone from US store shelves in response to warning letters that the US Food and Drug Administrati...

Genetic Learning of Nash Equilibria in Illicit Drug Markets and Prerequisites for a Successful Crackdown

Prescribing opioids during the diversion crackdown.

291 participating. Investigative tactics include offering arrested patients the opportunity to serve as confidential informants, covertly interviewing physicians’ current or former employees, and scheduling appointments with physicians to seek prescriptions for opioids, often secretly recording office visits. Successfully responding to investigations requires physicians to demonstrate proactive...